Collagen or whey. Which should you choose?
For years, collagen/gelatin was maligned by bodybuilding enthusiasts as an “incomplete protein” because it doesn’t contain all the essential amino acids, nor does it contribute directly to muscle protein synthesis. There’s definitely truth to this. If you ate nothing but gelatin for your protein, you’d get sick real quick. That’s exactly what happened to dozens of people who tried the infamous “liquid protein diet” fad of the 70s and 80s, which relied heavily on a gelatin-based protein drink. Man—or woman—shall not live by collagen alone.
As for whey, it’s an extremely complete protein. It’s one of the most bioavailable protein sources around, a potent stimulator of anabolic processes and muscle protein synthesis. I consider it essential for people, especially older ones in whom protein metabolism has degraded, and for anyone who wants to boost their protein intake and get the most bang for their buck.
This said, which is best for your needs today? Let’s take a look….
Collagen and whey are two completely different foods. Whether you take one or the other depends on a number of factors.
The first thing to do is explore the different benefits and applications of whey and collagen.
Whey Protein: Uses and Benefits
Whey is one of two primary dairy proteins, the other one being casein. It gained its reputation in the fitness world as a proven muscle-builder, but it actually has some interesting health effects that have little to do with hypertrophy.
In fact, whey is more than just protein. It also includes bioactive components such as lactoferrin (which improves bone health), beta-lactoglobulin (which can promote glutathione synthesis and protect against allergy), alpha-lactoalbumin (which can improve resistance to the cognition-depleting effects of stress), and immunoglobulins (which have antimicrobial effects). Whey also turns into some interesting peptide metabolites upon digestion which, according to a review, can improve blood lipids and lower blood pressure.
What Are Some Good Applications Of Whey?
Obesity: Whey tends to reduce fasting insulin levels in the obese and overweight (but not healthy prepubertal boys, who could use the growth promotion), increase satiety, reduce food intake, and improve resting energy expenditure. If you’re trying to lose weight or prevent obesity, you can’t ask for a better trifecta than increased energy burning, increased satiety, and reduced intake.
Diabetes: Eaten before a meal, whey reduces the glucose spike from the subsequent meal in non-diabetics and type 2 diabetics alike. It achieves this by “spiking” insulin, but transiently; the insulin area under the curve improves even as the immediate insulin response increases. Plus, as seen above, fasting insulin tends to lower in people consuming whey protein. Spikes are not persistent elevations.
Fatty liver: In obese women, a whey supplement reduces liver fat (and as a nice side effect increases lean mass a bit). Fatty liver patients also benefit from whey, enjoying improvements in glutathione status, liver steatosis, and antioxidant capacity. Rats who supplement with whey see reduced fat synthesis in the liver and increased fatty acid oxidation in the skeletal muscle.
Stress: In “high-stress” subjects, a whey protein shake improved cognitive function and performance by increasing serotonin levels. The same shake had no effect on “low-stress” subjects. And dietary whey also lowers oxidative brain stress, at least in mice.
Cancer: Both the lactoferrin found in whey and the glutathione synthesis whey promotes may have anti-cancer effects. Lactoferrin shows potential to prevent cancer that has yet to occur and induce cell death in existing cancer cells. In a recent human study, oral lactoferrin suppressed the formation of colonic polyps. And in animal cancer studies and human cancer case studies, whey protein has been shown to increase glutathione (“foremost among the cellular protective mechanisms”) and have anti-tumor effects.
HIV: People with HIV experience a drastic reduction in glutathione levels. As the master antioxidant, getting glutathione higher is pretty important. Whey won’t cure anything, but it does improve CD4 (a type of white blood cell) count, lower the number of co-infections, and persistently increase glutathione status.
Cardiovascular disease: Last year, a review of the effect of whey on major cardiometabolic risk factors found that whey protein improves the lipid profile, reduces hypertension, improves vascular function, and increases insulin sensitivity and glucose tolerance. Whey peptides that form during digestion actually act as ACE-inhibitors, reducing blood pressure similarly to pharmaceuticals without the side effects.
Sarcopenia: Muscle wasting, whether cancer-related or a product of age and inactivity, is a huge threat to one’s health and happiness. Studies show that whey protein is the most effective protein supplement for countering sarcopenia, especially compared to soy. An anti-sarcopenia smoothie I always have people drink on bed rest is 20-30 grams of whey isolate, a couple egg yolks, milk, cream, and ice. Tastes like ice cream and works like a charm. One time a friend even gave this to his grandmother who was on bedrest in the hospital with diarrhea, mental confusion, and a total lack of appetite. She was in a bad state. After a day or two of the smoothie, she recovered quite rapidly, regaining her appetite and alertness.
Gastrointestinal disorders: Dairy gets a bad rap in some corners for its supposed effects on the gut, but a component of dairy can actually improve gut health, even in patients with gastrointestinal disorders. In Crohn’s disease patients, a whey protein supplement reduces leaky gut. In rodent models of inflammatory bowel disease, whey protein reduce gut inflammation and restore mucin (the stuff used to build up the gut barrier) synthesis.
Oh, and whey is great for hypertrophy.
When To Choose Whey
- If you lift and want some extra protein, whey’s a great choice.
- If you’re older and worry about your ability to metabolize and utilize protein, some extra protein via whey can help.
- If you have any of the conditions listed above, whey’s a great choice. Do note that some of the benefits may stem from simply eating more protein than before. Whey itself may not be the whole cause; an extra slab of steak or a few more eggs could possibly have the same effect.
Along with foods like organ meats, egg yolks, and shellfish, I consider whey to be an important “supplemental food”—a food that acts like a high-density nutrition supplement, powerful in small doses and worth including in almost every diet.
Collagen Protein: Uses and Benefits
I advocate collagen protein as a fourth macronutrient. It’s different enough from whey and other “regular” proteins, serving a totally different function in the body.
If whey has been the gold standard for the muscle building amino acid profile for 30 years, collagen is the gold standard for supporting collagen-based structures in the body (fascia, ligaments, tendons, cartilage, skin, hair, nails). We don’t get much collagenous material in a normal diet these days, and meat proteins and/or plant proteins and/or milk, eggs, etc. don’t have the collagen peptides nor the ideal ratio of glycine, hydroxyproline, and other amino acids found abundantly in collagen. Furthermore, metabolism of the amino acids present in muscle meat deplete our reserves of glycine, thereby increasing the requirement even further. The more meat you eat, the more collagen you need.
Why We Need Collagen So Much These Days
This (non)relationship with collagen is extremely novel for our species. For millions of years up until very recently we ate nose to tail. We ate the entire animal. To give you an idea of how much collagen we’d have eaten, the average cow is about half muscle meat and half “other stuff,” which includes bones, skin, tendons, ligaments, fascia, and other bits extremely rich in collagen. That’s a ton of glycine and a far cry from eating nothing but ground beef and ribeyes. And more recently, even when we moved toward shrink-wrapped select cuts of meat and away from bones and skin, we still had jello. Then, when jello got maligned, we had nothing. So for the past 20-30 years or so, most Americans have had no appreciable source of collagen peptides in their diet.
Just based on what we know about human biochemistry, this is a disaster. The human body requires at least 16 grams of glycine per day for basic metabolic processes, yet we can only synthesize 3 grams, and the typical omnivorous diet provides just 2-3 grams per day, so we’re looking at an average daily deficit of 10 grams that we need to make up for through diet. Collagen is roughly 1/3 glycine, so that means we need to be eating about 30 grams of collagen per day to hit our 10 gram dosage. And in disease states that disrupt glycine synthesis, like rheumatoid arthritis, or on plant-based diets that provide little to no dietary glycine, we need even more.
I suspect a lot of pro athletes who have connective tissue issues could use even more collagen, especially since they’re exposing their tissues to such incredible stress. I know I did back during my competition days.
What Does Collagen Do For Our Bodies?
It supports our connective tissue and collagen-based structures: fascia, ligaments, tendons, cartilage, skin, hair, and nails.
It improves sleep quality. Human studies show that 3 grams of glycine taken before bed increases the quality of your sleep and reduces daytime sleepiness following sleep restriction. Now that’s isolated glycine rather than collagen, but collagen is the best source of glycine. I can say that a big mug of bone broth or a couple scoops of collagen peptides before bed knock me out and give me great sleep.
It balances your muscle meat intake. I mentioned this earlier, and we see both observational and interventional evidence for it.
- Observational: In one recent observational study, the relationship between red meat and diabetes was abolished after controlling for low-glycine status. People with low glycine levels and high meat intakes were more likely to have diabetes; people with higher glycine levels could have higher meat intakes without any issues. In another study, low circulating levels of glycine predicted diabetes risk.
- Interventional: In both worms and rodents, excessive intake of methionine (the amino acid most abundantly found in muscle meat) reduced longevity, while adding in glycine restored it.
It improves gut health. When I gave up grains and stopped endurance training at age 47 my gut health improved immensely. Like, world-changing for me. But I was still at 90-95%. When I started supplementing with collagen, my gut finally had that last 5% of repair/support/healing it needed to get to 100%.
It’s a great pre-workout. Though maybe not for the reasons most people take “pre-workouts.” I’ve also experienced rapid healing of tendinitis through using pre-workout collagen with vitamin C. I’m not just imagining it because I’ve dealt with a ton of tendon issues over the years, and they never healed that quickly until I introduced pre-workout collagen.
I’ve noticed that my hair and nails grow much faster than before.
Final Answer: Which One?
So, should you use whey or collagen? Let’s get to the bottom line, Sisson.
I made Primal Fuel because I wanted a high quality, low-sugar, moderate-fat meal replacement whey protein.
Personally, I had a need for both.
If I had to choose one, collagen is a better choice for the vast majority of you.
Essential amino acids aren’t a big problem on most ancestral diets, like paleo, Primal, or Primal-keto, and if you’re eating enough animal protein you don’t really need whey. Now, can you benefit from whey despite eating meat? Sure. Necessary does not mean optimal; whey has been shown to improve hypertrophy and muscle recovery from resistance training, plus all the other benefits I already detailed earlier. Almost anyone who does anything in the gym will see benefits from adding 20 grams of whey per day.
But almost no one is getting enough collagen, even the ancestrally-minded eaters who are aware of its importance. And that is a historical aberration on a massive scale. It hasn’t been done before. I wouldn’t recommend testing those waters.
And of course, powders aren’t the only way to get collagen and whey. They both appear in plenty of foods. The powders are just convenient to have on hand when you forget to make the bone broth (chicken, beef, turkey) or throw the oxtails in the crockpot. (Check out those linked recipes if you prefer broth or stew sources.)
Which do you prefer—whey or collagen? What benefits have you noticed from each?
Thanks for reading, everyone. Let me know your thoughts, and take care.
Wodarski KH, Galus R, Brodzikowska A, Wodarski PK, Wojtowicz A. [The importance of lactoferrin in bone regeneration]. Pol Merkur Lekarski. 2014;37(217):65-7.
Markus CR, Olivier B, De haan EH. Whey protein rich in alpha-lactalbumin increases the ratio of plasma tryptophan to the sum of the other large neutral amino acids and improves cognitive performance in stress-vulnerable subjects. Am J Clin Nutr. 2002;75(6):1051-6.
Pal S, Ellis V, Dhaliwal S. Effects of whey protein isolate on body composition, lipids, insulin and glucose in overweight and obese individuals. Br J Nutr. 2010;104(5):716-23.
Hall WL, Millward DJ, Long SJ, Morgan LM. Casein and whey exert different effects on plasma amino acid profiles, gastrointestinal hormone secretion and appetite. Br J Nutr. 2003;89(2):239-48.
Shertzer HG, Krishan M, Genter MB. Dietary whey protein stimulates mitochondrial activity and decreases oxidative stress in mouse female brain. Neurosci Lett. 2013;548:159-64.
Bounous G. Whey protein concentrate (WPC) and glutathione modulation in cancer treatment. Anticancer Res. 2000;20(6C):4785-92.
Meléndez-hevia E, De paz-lugo P, Cornish-bowden A, Cárdenas ML. A weak link in metabolism: the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis. J Biosci. 2009;34(6):853-72.
The post Collagen vs. Whey: Which Protein is Best For Your Needs? appeared first on Mark’s Daily Apple.
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“Do not go gentle into that good night.” That’s one of my favorite lines in all of literature, and it informs my outlook on health, life, wellness, and longevity.
Live long, drop dead. Compression of morbidity. Vitality to the end. All that good stuff.
But I’m sorry to report that Dylan Thomas imploring you to assail life with boldness is becoming harder for the average person to fulfill and embody. People more than ever before are heading into middle age with a head-start on the degenerative changes to body composition and function that used to only hit older folks. They may want to go boldly into that good night, but their bodies probably won’t be cooperating.
Ignore the standouts for a moment. I’m not talking about that awesome granny you saw deadlifting her bodyweight on Instagram or the centenarian sprinter smoking the competition. I’m not talking about the celebrities with personal trainers and access to the latest and greatest medical technologies. I’m referring to the general trend in the greater population. All signs point to average men and women alike having more fragile bones, weaker muscles, and worse postures at a younger age than their counterparts from previous eras.
What Signs Point This Way?
Low Bone Density
These days, more men than ever before are developing the signs of osteoporosis at an earlier age. In fact, one recent study found that among 35-50 year olds, men were more likely than women to have osteopenia—lower bone mineral density—at the neck.
Osteoporosis used to be a “woman’s disease,” lower estrogen after menopause being the primary cause. That’s rather understandable; estrogen is a powerful modulator of bone metabolism in women, and a natural decline in estrogen will lead to a natural decline in bone density. Men’s bone density has a similar relationship with testosterone; as a man’s testosterone declined, so does his bone density. As long as a man or woman entered the decline with high bone density, the decline wouldn’t be as destructive.
But here’s the thing: these days, both men and women are starting the decline with lower bone density. In women and men, peak bone mass attainment occurs during puberty. In girls, that’s about ages 11-13. In boys, it’s later. Puberty sets up our hormonal environment to accumulate healthy amounts of bone mineral density—but we have to take advantage of that window.
One of the main determinants of bone density accumulation is physical activity. If you’re an 11-year-old girl or a 16-year-old boy and you’re not engaging in regular physical activity—running, jumping, throwing, lifting, playing—you will fail to send the appropriate signals to your body to begin amassing bone mass. And once that developmental window closes, and you didn’t spend it engaging in lots of varied movement, it’s really hard to make up for all the bone mineral density you didn’t get.
But you can certainly improve bone mineral density at any age. Even the elderly can make big gains by lifting weights, walking frequently, or even doing something a simple as regular hopping exercises. The problem is that physical activity is down across all ages.
Children are spending more time indoors using devices than outdoors playing. They aren’t walking to school or roaming around outdoors with friends getting into trouble. If they’re active, they’re more likely to be shuttled from soccer practice to ballet to music lessons. Their movement is prescribed rather than freely chosen. Hour-long chunks of “training” rather than hours and hours of unstructured movement…
Not just kids, either. Sedentary living is up in everyone.
So there are two big issues:
- Kids are squandering the developmental window where they should be making the biggest gains in bone density.
- Adults are leading sedentary lives, squandering the lifelong window we all have to increase bone density.
Another reason men are having newfound problems with low bone mineral density is that a generational drop in testosterone has been observed. Twenty years go, men of all ages had higher testosterone levels than their counterparts today, meaning an average 50-year-old guy in 1999 had higher testosterone than an average 50-year-old guy in 2019. Testosterone will decline with age. That’s unavoidable. But something other than aging is also lowering testosterone—and bone density—across the board.
Experts are now recommending that young men use night lights, avoid throw rugs on the floor, and do pre-emptive physical therapy—all to reduce the risk of tripping, falling, and breaking something. That is absolutely tragic. This shouldn’t be happening.
The smartphone is a great tool with incredible potential to transform lives, economies, and personal capacities. But it can wreck your posture if you’re not careful and mindful.
Try this. Pick up your phone and compose a text message. Do it without thinking. Now hold that position and go look at yourself in a mirror. What do you see?
Head jutting forward, tilted down.
Upper back rounded, almost hunched.
Shoulders internally rotated.
Now spend 6-8 hours a day in this position. Add a few more if you work on a computer. Add another 15-20 minutes if you take your phone into the bathroom with you. Add an hour if you’re the type to walk around staring at your phone.
It all starts to sound a little ridiculous, doesn’t it?
Not only are people spending their days sitting and standing with their spine contorted, they’re staring down at their phones while walking. This is particularly pernicious. They’re training their body to operate in motion with a suboptimal, subhuman spinal position. They’re making it the new normal, forcing the body to adapt. And it is subhuman. Humans are bipeds, hominids that tower over the grasslands, able to scan for miles in every direction, perceive oncoming threats, plot their approach, stand upright and hold the tools at the ready. What would a Pleistocene hunter-gatherer of 20,000 years ago make of the average 25-year-old hunchback shuffling along, nose pointed toward the ground? What would your grandfather make of it?
It used to be that the only person with a kyphotic, hunchback posture was pushing 70 or 80 years old. And even in that age group, it was relatively rare. Nowadays young adults, teens, and even kids have the posture.
Interest in effective fitness and healthy eating and CrossFit and paleo and keto and everything else we talk about is at an all-time high, and all your friends on Instagram seem to be drinking bone broth and doing squats, so you’d think that people are getting stronger and waking up from all the crazy conventional wisdom that society has foisted upon us over the years. They’re not, though. That’s the view from inside the Internet bubble. This explosion in ancestral health and fitness is a reaction to the physical ineptitude and torpor enveloping the modern world. A small but growing group of people are discovering the keys to true health and wellness because the world at large has become so backwards.
And no matter how many CrossFit gyms pop up or people you see walking around in yoga pants, the average adult today is weaker than the average adult from twenty years ago. That’s the real trend. It probably doesn’t apply to you, my regular reader, but it does apply to people you know, love, and work with. Here’s the reality:
Grip strength—one of the better predictors of mortality we have—of 20-34 year old men and women has declined since 1985, so much that they’re “updating the normative standards” for grip strength. Even 6-year-olds are weaker today.
New recruits in the military are weaker than recruits from previous eras. They’re even having trouble “throwing grenades.”
Everywhere you look—Lithuania, Portugal, Sweden, to name just a few—kids, teens, and adults of all ages are failing to hit the normative standards of strength and fitness established in older eras. People are getting weaker, softer, and less fit earlier than ever before.
Don’t let this happen to you. Don’t let it happen to the people you care about. You have the chance, the duty to your future self to go boldly into that good night, rather than wither and dwindle and fall apart. And it starts today, right now, right here. Do one thing today. What will it be?
How are you guys fighting the ravages of age and gravity? What are you going to do today to ensure you’ll go boldly into older age?
Bass MA, Sharma A, Nahar VK, et al. Bone Mineral Density Among Men and Women Aged 35 to 50 Years. J Am Osteopath Assoc. 2019;119(6):357-363.
Fain E, Weatherford C. Comparative study of millennials’ (age 20-34 years) grip and lateral pinch with the norms. J Hand Ther. 2016;29(4):483-488.
Larson CC, Ye Z. Development of an updated normative data table for hand grip and pinch strength: A pilot study. Comput Biol Med. 2017;86:40-46.
Venckunas T, Emeljanovas A, Mieziene B, Volbekiene V. Secular trends in physical fitness and body size in Lithuanian children and adolescents between 1992 and 2012. J Epidemiol Community Health. 2017;71(2):181-187.
Marques EA, Baptista F, Santos R, et al. Normative functional fitness standards and trends of Portuguese older adults: cross-cultural comparisons. J Aging Phys Act. 2014;22(1):126-37.
Ekblom B, Engström LM, Ekblom O. Secular trends of physical fitness in Swedish adults. Scand J Med Sci Sports. 2007;17(3):267-73.
The post Is 50 the New 70? How the Modern Lifestyle Is Remaking Middle Age appeared first on Mark’s Daily Apple.
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When you stop to think about it, mushrooms are remarkable.
They’re closer to animals than plants on the tree of life.
They can break down plastic and petroleum.
The single largest organism on the planet is an underground honey fungus spanning almost 3 miles in the the state of Oregon.
They carry messages along their underground fungal networks using neurotransmitters that are very similar to the ones our brains use.
They’re a kind of “forest internet” which plants and trees use to communicate with each other.
And, as it turns out, they possess and confer some very impressive health and therapeutic effects. Several years ago, I highlighted the culinary varieties and explored their considerable health benefits. Go read that, then come back here because I’m going to talk about the different types of adaptogenic mushrooms today. These are the real heavy hitters, the ones that appear to supercharge immune systems, stimulate neuronal growth, improve memory and focus, pacify the anxious mind, increase the libido, and enhance sleep quality.
Let’s go through the most important adaptogenic mushrooms and the evidence for each. I’ll primarily stick to human studies, but may relay some animal studies if they seem relevant.
Reishi has been used in traditional Asian medicine for hundreds of years to treat diseases of the immune system. (Reishi is its Japanese name; in China, it’s called lingzhi and in Korea, it’s yeongji.) Other folk uses include all the regular stuff you expect—aches, pains, allergies, “qi”—but the majority of modern clinical evidence focuses on immunity, cancer, and inflammation.
But the interesting thing to remember is that inflammation figures into pretty much every modern ailment. Even conditions like depression and anxiety are often characterized by a surplus of systemic inflammation. If reishi can soothe the inflammation, it could very well help with all the other seemingly unrelated conditions, too.
- Reduced anxiety, depression, and fatigue and improved quality of life in breast cancer patients.
- Reduced insulin resistance.
- Reduced inflammatory markers and restored kidney function in kidney disease patients.
- Suppressed the growth of more adenomas (benign tumors with the potential to become malignant) in patients with existing colorectal adenomas.
- Boosted the immune systems of late-stage cancer patients.
Reishi is also said to be very good for sleep, though I wasn’t able to find a supporting human study.
Exercise caution if you have an autoimmune disease, as using reishi to”activate” the immune system that’s attacking you may—theoretically—increase the attack’s severity.
Reishi may also lower libido in high doses, as it inhibits the conversion of testosterone to dihydrotestosterone—albeit in rats. More rat research suggests that low doses of reishi could increase libido.
No human studies indicate this, but a rodent study found that giving reishi reduced time to exhaustion in a forced weighted swimming challenge (throw a rat in the water with a weight attached). They got tired faster.
Cordyceps is another mushroom used in traditional Chinese medicine to promote vitality and energy. For the men, that’s code for “better erections.” What does the evidence say?
It is broadly anti-inflammatory.
It’s an effective immuno-adaptogen: it boosts immunity when immune function is too low and dampens it when it’s over-activated. Autoimmune thyroiditis patients who took cordyceps saw dual-direction immunomodulation—too low got higher, too high got lower.
As for the “energy and vitality” claims, that appears to be true in mammals. We have evidence that rats, pigs, mice, and even yaks, goats, and sheep get boosts to testosterone status and sexual function when taking cordyceps, and that it improves brain function and cognition in small mammals, but nothing solid in humans. Still, the fact that it helps other mammals probably indicates utility for us.
Chaga is a mushroom with a long history of use in Northern Eurasia (Russia, Siberia) as well as a considerable body of animal evidence and isolated human cell evidence in support, but no real studies using actual live humans. That’s unfortunate, because chaga appears to be the real deal:
- Immunomodulation (mice).
- Increased endurance and improved lactate threshold during exercise (mice).
- Reduced cancer progression and spread (mice).
- Reduced DNA damage (human cells).
I hope we get some strong human studies in the near future. In the meantime, you can always run your own!
Lion’s Mane is a mushroom that looks like a pom-pom. Or a brain, which is fitting. Lion’s Mane’s main claim to fame is its purported ability to increase neurogenesis, reduce cognitive decline, and even regrow damaged nerves.
Studies in fact show that Lion’s Mane can:
- Reverse mild cognitive decline in the elderly (for as long as they continue to take the mushroom).
- Help nerve-damaged rats regenerate destroyed nerves and regain their ability to walk.
- Improve the Functional Index Measure in patients with dementia.
- Reduce anxiety and depression in women.
The majority of Lion’s Mane customers aren’t interested in reducing decline. They want a boost. They want increased focus, improved cognition, more and better neurons. Judging from the reversal of cognitive decline in the elderly and the flood of online anecdotes about improved focus and cognition, I suspect that there’s something there.
That said, another common side effect I’ve heard about from many of the same people lauding its cognitive effects is reduced libido. So keep an eye out for that one.
You know how I do things here. I can’t in good faith make definitive claims based on mouse studies that show this or that mushroom improving memory, blasting tumor cells, and increasing sexual virility. Still, I also can’t discount the hundreds (and in some cases, thousands) of years of traditional use of these mushrooms for many of the conditions, nor can I ignore (or write off as “placebo”) the thousands of experimenters out there online deriving major benefits from some of these mushrooms.
The only option, of course, is to try it for yourself, which I may do in the near future (and will write about my findings).
How to Choose a Mushroom Supplement
When you’re buying an adaptogenic mushroom extract, look for products that come from fruiting bodies (actual mushrooms) rather than mycelium (the “roots” of the mushrooms). Fruiting bodies tend to have more of the active constituents than mycelium. Fruiting body extracts will also be more expensive—mushrooms take longer to grow than mycelium—but the added potency makes up for it.
Look for products that list the beta-glucan content, not the polysaccharide content. Beta-glucans are the uniquely active constituents. All beta-glucans are polysaccharides, but not all polysaccharides are beta-glucans.
In the meantime, I’d love to hear your experiences with adaptogenic mushrooms. Have you tried them? How have they been useful for you (or not)? Thanks for stopping in, everybody.
Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614.
Futrakul N, Panichakul T, Butthep P, et al. Ganoderma lucidum suppresses endothelial cell cytotoxicity and proteinuria in persistent proteinuric focal segmental glomerulosclerosis (FSGS) nephrosis. Clin Hemorheol Microcirc. 2004;31(4):267-72.
Smiderle FR, Baggio CH, Borato DG, et al. Anti-inflammatory properties of the medicinal mushroom Cordyceps militaris might be related to its linear (1?3)-?-D-glucan. PLoS ONE. 2014;9(10):e110266.
Lin WH, Tsai MT, Chen YS, et al. Improvement of sperm production in subfertile boars by Cordyceps militaris supplement. Am J Chin Med. 2007;35(4):631-41.
Parcell AC, Smith JM, Schulthies SS, Myrer JW, Fellingham G. Cordyceps Sinensis (CordyMax Cs-4) supplementation does not improve endurance exercise performance. Int J Sport Nutr Exerc Metab. 2004;14(2):236-42.
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